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In 1774, Spanish explorer established an overland route from Arizona to California, with part of the passing through present day Upland on the way to the San Gabriel Mission. Anza's route went through , the and through the San Bemardino Valley. In 1775, Anza led a second expedition consisting of more than 240 people on a journey of over two thousand miles to the . En route, the expedition reached the San Gabriel Mission on January 4, 1776. The expedition reached the San Francisco Bay on June 27, 1776, where Anza founded the present day city of . Five years later, in 1781, Spanish settlers followed Anza's route to found the city of a few miles west of the San Gabriel Mission.
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Following the Anza expedition, the San Gabriel Mission became an important stopping place for expeditions traveling between Arizona and California. The mission was the first place where supplies could be procured after crossing the desert, and as travel over this road increased, the mission arranged to establish a supply station at some intermediate point east. In 1810, a party of missionaries, soldiers, and Native Americans from San Gabriel mission, under the leadership of Padre Dumetz, were sent out to select a location. On the 20th of May, 1810, they came into the San Bernardino Valley. This, according to the Roman Catholic Calendar of Saints, was the feast day of Saint , and they named the valley in his honor. The expedition named the area around Upland "Cucamonga," which in the language meant "sand place."
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